Port St. Joe is a city located at the intersection of U.S. Highway 98 and State Road 71 and the county seat of Gulf County, Florida. As of the 2020 census,the population was 3,357. This was a decline from 3,644 as of the 2000 census.

St. Joseph was founded in 1835 by businessmen from nearby Apalachicola, which was troubled by legal conflict over land titles.[3] It was mostly abandoned in 1841 after a yellow fever epidemic; a storm surge produced by a hurricane in 1844 destroyed what structures remained.[4] During the Civil War, Florida was a leading producer of salt for the Confederate army. On September 15, 1862, a Union officer on board the USS Kingfisher wrote that he an his men had sent a demand to the extensive salt works at Saint Joseph that they cease production. When the work was not halted, the Kingfisher went into Saint Joseph bay, sent at least 50 men in land, and destroyed the salt works.[5] In the early 20th century a new settlement was founded close to the original after the arrival of the Apalachicola Northern Railroad in 1909. It appears that the more informal “Port St. Joe” was adopted for official use around this time.